Matrix Metalloproteinases in the Central Nervous System

Matrix Metalloproteinases in the Central Nervous System

eBook - 2005
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This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and chemokines, and cell surface receptors. Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered. The book also touches on studies suggesting that, in certain situations, dysregulated MMP activity and/or production may be critical to blood-brain barrier breakdown and neuronal damage.
Publisher: London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific, ©2005
ISBN: 9781860947179
1860947174
9781281866974
1281866970
1860945597
9781860945595
Characteristics: 1 online resource (vii, 337 pages) : illustrations
Additional Contributors: Conant, Katherine
Gottschall, Paul E.

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