Parkinson's Disease

Parkinson's Disease

eBook - 2002
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Book News
Fifteen papers from an October 2000 conference review the role of receptors, ion channels, and proteins in the etiology of Parkinson's disease, and report on clinical experience with novel drug candidates. The contributors explore models of basal ganglia function, the treatment of drug-induced psychosis and depression, and a novel anti- parkinsonian agent with anti-depressant and anxiolytic properties. Other topics include neuronal cell death and apoptosis in neurodegenerative diseases, parkinsonian features of the ataxia-telangiectasia and atm-deficient mice, and an immortalized neuronal cell line derived from the substantia nigra of a rat. No subject index. Annotation (c) Book News, Inc., Portland, OR (

Blackwell North Amer
This book is the proceedings of the first Solvay Pharmaceuticals research symposium, and is dedicated to Parkinson's disease and provides an update of clinical and preclinical research. Parkinson's disease is a progressive neurodegenerative disorder, primarily affecting dopaminergic neurons in the substantia nigra and resulting in a number of symptoms. While these symptoms can be treated with conventional therapy, this book contains several chapters discussing innovative approaches for the symptom treatment of Parkinson patients, aiming for reducing severe side effects of current treatment, such as dyskinesias, dystonia, insomnia. In addition, attention is focused to the comorbid major depression and its treatment, as the latter affects quality of life more severely than the motor dysfunction that is the hallmark of Parkinson's disease. The second part of these proceedings is devoted to the molecular and cellular basis of the degenerating brain. Current insights on mitochondrial dysfunction, induction of cytoprotective systems and the use of neurotropic factors, all aiming at attenuating the degeneration process are discussed. As the potential therapeutic effects of such neuroprotective approaches may not be readily visible in current clinical settings, a clear need for surrogate markers is required. As is discussed in this book, neuroimaging such as PET, SPECT and MRI may serve in future to evaluate innovative therapy that is aimed at conserving dopaminergic neurons in Parkinson's disease.

Publisher: Amsterdam ; Washington, DC : IOS Press, ©2002
ISBN: 9780585458823
Characteristics: 1 online resource (viii, 159 pages) : illustrations
data file,rda
Additional Contributors: Ronken, E.
Scharrenburg, G. J. M. van


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